Elucidation of sodium potassium atpase activity of epileptic rat brain synaptosome by neurotransmitters
نویسندگان
چکیده
منابع مشابه
Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase.
Previous studies have demonstrated that electrically induced seizures in rat result in an increased brain intracellular sodium which can be decreased by treatment with sodium diphenylhydantoin (DPH). The correlation of cation transport with membrane-oriented sodium-potassium-adenosine triphosphatase (Na-K-ATPase) prompted an investigation of the effect of DPH upon ATPase enzyme activity.Rat cer...
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The hitherto unknown NT-regulated mechanism of NaK-ATPase localized in the nerve ending membranes is found. The mechanism certainly has a functional significance and must be involved in the regulation – modulation of chemical synaptic transmission. On the other hand , the availability of the discovered specific protein, regulators (SFa and SFi) of synaptic origin, makes it possible to consider ...
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To explore the action mechanism of lithium in the brain, the author investigated the effects of lithium on Na-K ATPase and Ca ATPase in rat brain synaptosomes prepared from forebrains by the method of Booth and Clark. The activities of Na-K ATPase and Ca ATPase were assayed by the level of inorganic phosphate liberated from the hydrolysis of ATP. Lithium at the optimum therapeutic concentration...
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Since Skou (1) and Post et al. (2) reported, it has been well known that the active trans port of ions across the cell membrane is closely related to the (Na+ H K+)-stimulated ATP ase in the membrane. It is also accepted that mitochondria take up and extrude several kinds of ions from and into the surrounding medium (3-6). Relations between an ion transport and the ATPase activity in mitochondr...
متن کاملEvaluation of Brain Neurotransmitters by Morpho-Functional Method
SUMMARY This review discribes some of the morphological tools which have allowed not only to discribe the chemical nature of neuronal pathways in the central nervous system but also to approach their physiology and their functions: Enzyme histochemistry; this technique shows the entity of an enzyme in nervous tissue. Immunocyto-histochemistry; based on antigenantibody reaction constitute the ...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2019
ISSN: 0022-510X
DOI: 10.1016/j.jns.2019.10.866